Sparta, Breanne; Kosaisawe, Nont; Pargett, Michael; Patankar, Madhura; DeCuzzi, Nicholaus; Albeck, John G;

Elife, 2023, Volume: 12 Issue: 0, doi: 10.7554/eLife.74903

Transient phases of OXPHOS inhibitor resistance reveal underlying metabolic heterogeneity in single cells

Kosaisawe, Nont; Sparta, Breanne; Pargett, Michael; Teragawa, Carolyn K; Albeck, John G;

Cell Metabolism, 2021, Volume: 33 Issue: 3, doi: 10.1016/j.cmet.2021.01.014

Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate

Guo, Liang; Zhu, Kan; Pargett, Michael; Contreras, Adam; Tsai, Patrick; Qing, Quan; Losert, Wolfgang; Albeck, John; Zhao, Min;

Iscience, 2021, Volume: 24 Issue: 11, doi: 10.1016/j.isci.2021.103240

Systems-Level Properties of EGFR-RAS-ERK Signaling Amplify Local Signals to Generate Dynamic Gene Expression Heterogeneity

Davies, Alexander E; Pargett, Michael; Siebert, Stefan; Gillies, Taryn E; Choi, Yongin; Tobin, Savannah J; Ram, Abhineet R; Murthy, Vaibhav; Juliano, Celina; Quon, Gerald;

Cell systems, 2020, Volume: 11 Issue: 2, doi: 10.1016/j.cels.2020.07.004.

Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway

Gillies, Taryn E; Pargett, Michael; Silva, Jillian M; Teragawa, Carolyn K; McCormick, Frank; Albeck, John G;

Molecular systems biology, 2020, Volume: 16 Issue: 10, doi: 10.15252/msb.20209518.

Controlling ERK activation dynamics in mammary epithelial cells with alternating electric fields through microelectrodes

Guo, Liang; Li, Houpu; Wang, Yuan; Li, Zhuo; Albeck, John; Zhao, Min; Qing, Quan;

Nano Letters, 2019, Volume: 19 Issue: 10, Primary

Encoding growth factor identity in the temporal dynamics of FOXO3 under the combinatorial control of ERK and AKT kinases

Sampattavanich, Somponnat; Steiert, Bernhard; Kramer, Bernhard A; Gyori, Benjamin M; Albeck, John G; Sorger, Peter K;

Cell systems, 2018, Volume: 6 Issue: 6, doi: 10.1016/j.cels.2018.05.004

Entosis is induced by glucose starvation

Hamann, Jens C; Surcel, Alexandra; Chen, Ruoyao; Teragawa, Carolyn; Albeck, John G; Robinson, Douglas N; Overholtzer, Michael;

Cell reports, 2017, Volume: 20 Issue: 1, doi: 10.1016/j.isci.2021.102902.

Linear integration of ERK activity predominates over persistence detection in Fra-1 regulation

Gillies, Taryn E; Pargett, Michael; Minguet, Marta; Davies, Alex E; Albeck, John G;

Cell systems, 2017, Volume: 5 Issue: 6, pii: S2405-4712(17)30489-1.

Relaxation oscillations and hierarchy of feedbacks in MAPK signaling

Kochańczyk, Marek; Kocieniewski, Paweł; Kozłowska, Emilia; Jaruszewicz-Błońska, Joanna; Sparta, Breanne; Pargett, Michael; Albeck, John G; Hlavacek, William S; Lipniacki, Tomasz;

Scientific reports, 2017, Volume: 7 Issue: 1, Primary

Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells

Hung, Yin P; Teragawa, Carolyn; Kosaisawe, Nont; Gillies, Taryn E; Pargett, Michael; Minguet, Marta; Distor, Kevin; Rocha-Gregg, Briana L; Coloff, Jonathan L; Keibler, Mark A;

eLife, 2017, Volume: 6 Issue: 0, doi: 10.7554/eLife.27293.

Phosphoinositide 3-kinase regulates glycolysis through mobilization of aldolase from the actin cytoskeleton

Hu, Hai; Juvekar, Ashish; Lyssiotis, Costas A; Lien, Evan C; Albeck, John G; Oh, Doogie; Varma, Gopal; Hung, Yin Pun; Ullas, Soumya; Lauring, Josh;

Cell, 2016, Volume: 164 Issue: 3, Primary

Receptor-Level Mechanisms Are Required for EGF-Stimulated ERK Activity Pulses

Sparta, Breanne; Pargett, Michael; Minguet, Marta; Distor, Kevin; Bell, George; Albeck, John G;

Journal of Biological Chemistry, 2015, Volume: 0 Issue: 0, pii: jbc.M115.66224.

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

Shestov, Alexander A; Liu, Xiaojing; Ser, Zheng; Cluntun, Ahmad A; Hung, Yin P; Huang, Lei; Kim, Dongsung; Le, Anne; Yellen, Gary; Albeck, John G;

Elife, 2014, Volume: 3 Issue: 0, Primary

Accurate information transmission through dynamic biochemical signaling networks

Selimkhanov, Jangir; Taylor, Brooks; Yao, Jason; Pilko, Anna; Albeck, John; Hoffmann, Alexander; Tsimring, Lev; Wollman, Roy;

Science, 2014, Volume: 346 Issue: 6215, 346(6215):1370-3.

Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals

Albeck, John G; Mills, Gordon B; Brugge, Joan S;

Molecular cell, 2013, Volume: 49 Issue: 2, 49:1-13.

Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2

Worster, Devin T; Schmelzle, Tobias; Solimini, Nicole L; Lightcap, Eric S; Millard, Bjorn; Mills, Gordon B; Brugge, Joan S; Albeck, John G;

Science signaling, 2012, Volume: 5 Issue: 214, 5(214):ra19.

Reviews

A guide to ERK dynamics, part 2: downstream decoding

Ram, Abhineet; Murphy, Devan; DeCuzzi, Nicholaus; Patankar, Madhura; Hu, Jason; Pargett, Michael; Albeck, John G;

Biochemical Journal, 2023, Volume: 480 Issue: 23, doi: 10.1016/j.devcel.2022.09.001.

A guide to ERK dynamics, part 1: mechanisms and models

Ram, Abhineet; Murphy, Devan; DeCuzzi, Nicholaus; Patankar, Madhura; Hu, Jason; Pargett, Michael; Albeck, John G;

Biochemical Journal, 2023, Volume: 480 Issue: 23, . doi: 10.1016/j.devcel.2022.09.001.

Temporal coding of ERK signalling in β-cells

Huising, Mark O; Albeck, John G;

Nature Reviews Endocrinology, 2021, Volume: 17 Issue: 9, doi: 10.1038/s41574-021-00527-9.

Experimental and engineering approaches to intracellular communication

Albeck, John G; Pargett, Michael; Davies, Alexander E;

Essays in biochemistry, 2018, Volume: 62 Issue: 4, doi: 10.1042/EBC20180024.

Microenvironmental signals and biochemical information processing: cooperative determinants of intratumoral plasticity and heterogeneity

Davies, Alexander E; Albeck, John G;

Frontiers in cell and developmental biology, 2018, Volume: 6 Issue: 0, doi: 10.3389/fcell.2018.00044.

Publications

Research

Continuous sensing of nutrients and growth factors by the mTORC1-TFEB axis